Amyloid beta precursor protein (APP) and prion protein (PrP) are cell membrane elements implicated in neurodegenerative diseases. Both proteins undergo endoproteolysis. Evidence is adduced from the literature hinting that the process in the two proteins could be related, their functions may overlap and their distributions coincide. It is proposed that PrP catalyses its own cleavage, the C-terminal fragment functions as an α secretase and the N-terminal segment chaperones the active site; the α secretase releases anticoagulant and neurotrophic ectodomains from APP. (...) The proposals explain some features of spongiform encephalopathies. BioEssays 23:456–462, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Sermons of ʻAbdullāh Shāh, b. 1872, Islamic scholar, on Islamic customs and practices and Muslim ethics.

On the teachings of Prophet Muḥammad, d. 632 with reference to humanity.

Chemistry textbooks are the most popular teaching material in schools. They can contribute significantly to the attainment of scientific educational goals. Internationally, educational reforms in science subjects are adopting newer practices such as Engineering Design Processes for addressing real-world requirements. This study, conducted in Saudi Arabia, employed a qualitative and quantitative content analysis method to evaluate the level of the EDP incorporated in the tenth grade chemistry textbook and accompanying student’s experiments’ guidebook. The results found the inclusive mean for EDP (...) was 1.05, which indicated incorporation was found to be at level one. This inclusion EDP in chemistry textbooks has been rated as novice or deficient, which indicates that it does not fulfill the majority of the requirements for inclusion as suggested by NGSS. (shrink)

The Qurʾānic term, ‘ẓann,’ is usually understood and translated as conjecture. However, I argue that the Qurʾān uses ‘ẓann’ to mean dogmatic zeal or, in other words, being zealous to a certain belief. For conjecture, the Qurʾān uses the root ‘ḥ-s-b,’ such as, ‘ayaḥsabu.’ Although the Qurʾān may criticize some people's conjectures, it does not criticize the act of formulating opinions with the root ‘ḥ-s-b.’ However, the Qurʾān does criticize the act of ‘ẓann.’ This further emphasizes the distinction between conjecture (...) and ‘ẓann,’ according to the Qurʾān. The main emphasis is that when the Qurʾān requires people to shun most ‘ẓann,’ it is argued that it is asking to shun zealous beliefs and dogmas, and it is not asking to shun the formulation of conjectures. The method used is philological, in which the cognates are analyzed in their contexts and compared with their uses in the Qurʾān. Defining ‘ẓann’ as dogmatic zeal rather than conjecture has far-reaching implications in understanding Qurʾānic epistemology and the epistemic process it expects its audience to have. (shrink)

This book is the first comprehensive attempt to explain Ibn ‘Arabî’s distinctive view of time and its role in the process of creating the cosmos and its relation with the Creator. By comparing this original view with modern theories of physics and cosmology, Mohamed Haj Yousef constructs a new cosmological model that may deepen and extend our understanding of the world, while potentially solving some of the drawbacks in the current models such as the historical Zeno's paradoxes of motion (...) and the recent Einstein-Podolsky-Rosen paradox (EPR) that underlines the discrepancies between Quantum Mechanics and Relativity. (shrink)

Considering that in times of state of emergency or civil emergency (such as the pandemic caused by COVID 19), governments in many countries around the world have restricted human rights and freedoms through legally binding government decrees. These restrictive measures increasingly raise dilemmas about their effect and possible violations by the government of international norms guaranteeing human rights. The paper aims to analyze whether these restrictive measures set out in the decisions of the Government of the Republic of Northern Macedonia (...) (RNM) are in compliance with the derogations allowed under the European Convention on Human Rights and Freedoms (ECHR) and the positive laws in power. In the framework of this paper is analyzed whether these measures have the sole purpose of protecting the health of citizens or not. The work is limited in terms of time (as long as the state of emergency lasted three months) and territory (government decrees with the force of law). Descriptive, historical, analytical, comparative and citizen survey methods are used in this paper. Government decrees have been analyzed in order to assess whether they were prudent, in accordance with international standards and consequences that they have caused to citizens. The conclusions provide data on whether the management of the situation has been appropriate or not and to what extent it has been effective, as well as how much it has been within the international framework and how they have affected the quality of life of citizens. (shrink)

A comparison between Muḥammad and Siddhārtha’s psychological states is made to identify how they had their mystical experiences and how their presuppositions and personalities shaped their interpretation of these experiences. Muḥammad’s mystical experience appeared to be based on an altered state of consciousness. Siddhārtha’s teachings include that one must not have blind faith and remain open to various truths. These teachings may reflect that he was high in openness to experience, which may have fortified him from becoming delusional. While mystical (...) experiences may have pathological overlaps, they could be categorized in a similar way to psychological states. Yet, mindful presuppositions and personality traits, especially from within openness to experience spectrum, are what make perceptions of these experiences diverse. (shrink)

ABSTRACTThe unprecedented progress in bio‐medical sciences and technology during the last few decades has resulted in great transformations in the concepts of health and disease, health systems and healthcare organisation and practices. Those changes have been accompanied by the emergence of a broad range of ethical dilemmas that confront health professionals more frequently. The classical Hippocratic ethical principles, though still retaining their relevance and validity, have become insufficiently adequate in an increasing range of problems and situations. Healthcare that has been (...) practised for centuries on the basis of a direct doctor‐patient relationship has been increasingly transformed into a more complex process integrating the health‐team, the patient and the community. Systematic review of the specialised literatures revealed that Healthcare Ethics education has become a basic requirement for any training programme for health professionals, and should cover the different stages of undergraduate, postgraduate and continuing education. Both theoretical foundations and practical skills are required for the appropriate ethical reasoning, ethical attitude and decision‐making abilities. There is growing evidence that physicians’ professional and moral development is not only determined by the formal curriculum of ethics; rather more, it is determined by the moral environment of the professional practice, the ‘hidden curriculum’ which deserves serious consideration by medical education. (shrink)

The purpose of this study is to propose and develop an intelligent e-learning system based on advanced document management techniques at Al-Quds Open University. In this article, we focus on a case using e-mail contents as supplement educational materials at QOU. We describe how the interactive classification system based on concept hierarchy can simplify this task. This system provides the functions to index, classify, and retrieve a collection of e-mail messages based on user profiles. By automatically indexing e-mail messages using (...) our E-mail Classification System for e-Learning, instructors and/or students can easily find their messages and find the topics. The test results of our system evaluation showed that a good classification quality has been achieved, with a precision of 77.4%, recall of 90%, and F-measure of 82.8. (shrink)

The aim of the study was to study heuristic and interactive technologies in teaching informatics at a pedagogical university as a means of developing students' thinking flexibility. The main method used in this research work is the analysis of scientific and pedagogical literature. It was concluded that the integration of heuristic and interactive technology in teaching informatics is a pedagogical condition for the formation of flexibility of thinking of students of a pedagogical university.

The Qur’an frequently abhors blind faith based on tradition in its arguments against non-believers. Nonetheless, the Qur’an repeatedly asks people to believe in its message. How does the Qur’an distinguish between both kinds of faith? This article investigates the type of epistemology the Qur’an expects from its audience. Linguistically, the Qur’anic concept of īmān may be compared to taking refuge in Buddhism, in that it is through experience and insight (prajñā), as portrayed in the Kālāma Sutta, and not zeal. The (...) Qur’an differentiates between two types of conviction, that which is received through discernment and understanding, and that which is blind. The Qur’an shows cues of an attempt to harmonise faith and reason. It does not entertain non-believers in their request to have supernatural physical proofs, but frequently reminds them to use their reason and observation. This opens further avenues of interfaith dialogue between Buddhism and Islam. (shrink)

We present a fully relativistic formulation of the theory of electron-nucleus Bremsstrahlung, within the context of self-field QED, as advanced recently by Barut and his co-workers. The Bremsstrahlung emission cross-section, reported here, is also shown to reduce to the standard correct nonrelativistic limit, in the dipole approximation.

Within the context of the time-reversed S-matrix approach to photoionization, and employing a recently proposed strong-field solution to the Schrödinger equation, analytic expressions for the atomic photoionization rates are obtained here without using the dipole approximation. We show that the absorbed photon momentum shows up as a forward-directed momentum component for the photoelectron. All the expressions reported in this work have the correct limits when the dipole approximation is used.

In the modern age, the confl ict between science and religion manifests itself in the debate between evolution and creation. If we adopt a creationist’s reading of the Qur’ān, we discover an interesting anomaly. Reading the Qur’ān literally does not necessarily provide the foundation of creationism. Creationists usually have in mind the concept of creatio ex nihilo, or ‘creation out of nothing’. However, in the Qur’ān, one of the words used for creation, khalaqnā, has the root khlq, which means ‘to (...) split’ or ‘to divide’. This root word may even apply to the biological process of cell division. Therefore, from a scientifi c perspective, using the word khlq to describe this physical process is not problematic. In addition, with close textual analysis of the Qur’ān, we realize that the word for creation ‘be’ does not truly describe the moment of creation, but rather that of ‘being’. The Qur’ān separates the notion of creation from being, which poses the question as to what the text constitutes as the ontological nature of the human being and the universe. Therefore, even if we do adopt a literal reading of the Qur’ān, we fi nd that it does not necessarily support a worldview that endorses creatio ex nihilo. (shrink)

In this article, I developed the CSR-19 scale to assess the perceptions company executives have of CSR actions during the COVID-19 pandemic and to conceptualize the economic, legal, social, and environmental aspects of CSR actions as a high-order construct. This paper's findings suggest that the legal, environmental, and social aspects of CSR actions are being perceived to positively contribute to companies' CSR actions, but the economic aspect of CSR actions is deemed to contribute negatively to companies' CSR actions. The 16-item (...) CSR-19 scale shows strong evidence of reliability as well as content, convergent, and discriminant validity in a sample of 211 Jordanian companies. Managerial implications and suggestions for applying the CSR-19 scale in future research are presented. (shrink)

The paper describes the design of an intelligent tutoring system for teaching Introduction to Computer Science-a compulsory curriculum in Al-Azhar University of Gaza to students who attend the university. The basic idea of this system is a systematic introduction into computer science. The system presents topics with examples. The system is dynamically checks student's individual progress. An initial evaluation study was done to investigate the effect of using the intelligent tutoring system on the performance of students enrolled in computer science (...) curriculum at Al-Azhar University, Gaza. The results showed a positive impact on the evaluators. (shrink)

As it is known, in the early Islamic period, that is, during the time of the Prophet and his companions it was not difficult to find answers to the questions. However, when we look at the later periods, we see that people who had just accepted Islam, belonging to many new cultures, asked new questions. It was not so easy to answer these questions merely based on the Qur'an and the Sunnah. For this reason, Kufa scholars considered it necessary to (...) use ijtihad with raʾy (free legal reasoning). They were subjected to a lot of criticism in that period and today because they resorted to raʾy while doing ijtihad. One of the two main schools that criticized the Ahl al-Ra’y the most was the Ahl al-Hadith (people of hadith) school. From the early days of the formation of the Hadith school of jurisprudence, the Iraqi school has been accused of abandoning the book and the Sunnah in the interpretation of Shari'ah rulings and preferring the rulings obtained by the intellectual method. This intellectual method that we are talking about has been the target of criticism in certain historical periods, sometimes in the name of ra’y, sometimes inthe name of qiyas (analogy), and sometimes in the name of istihsan. Abu Hanifa is one of the famous scholars who have been criticized by Ahl al-Hadith. This article deals with the life, works and school of ra’y of Abu Hanifa. (shrink)

"First published by Oxford University Press, 1916."--Title page verso.

In this paper, we give a step by step introduction to the theory of well quasi-ordered transition systems. The framework combines two concepts, namely (i) transition systems which are monotonic wrt. a well-quasi ordering ; and (ii) a scheme for symbolic backward reachability analysis. We describe several models with infinite-state spaces, which can be analyzed within the framework, e.g., Petri nets, lossy channel systems, timed automata, timed Petri nets, and multiset rewriting systems. We will also present better quasi-ordered transition systems (...) which allow the design of efficient symbolic representations of infinite sets of states. (shrink)

An English language translation accompanies the original Greek text of Aristotle's book about the nature of the state, constitutions, revolutions, democracy, and oligarchy.

The aim of this research was to set a proposed strategy for achieving institutional integrity in the University of Ha’il (UoH), Saudi Arabia, in the light of the National Centre of Assessment and Academic Accreditation (NCAAA) Standards. This was accomplished through acknowledging theoretical and philosophical frameworks of institutional integrity and their obstacles in university educational institutions and displaying the institutional standards of the National Centre of Assessment and Academic Accreditation. This research depended on the descriptive method and employed the (SWOT) (...) Analysis to examine the status of UoH. The research confirmed that UoH implemented policies to support institutional values and research integrity. Furthermore, the university has employed mechanisms and procedures for institutional values and mentorships and has a declared policy for disclosure of information and access of necessary information to all beneficiaries. The university needs to set some mechanisms in place to ensure fairness and equality in performance assessments or to implement integrity standards in processes of employment and recruitment. (shrink)

"Using hundreds of examples from newsrooms large and small, author Ron F. Smith challenges readers to determine how they would face moral dilemmas on the job. Chapters evaluate the search for principles, accountability, truth and objectivity, errors and corrections, diversity, "faking" the news, reporters and their sources, privacy, the government watch, deception, compassion, the business of news, journalists and their communities, and financial concerns. New to this edition: a chapter on improving coverage of minorities, expanded discussion of broadcast journalism and (...) reporting on the Internet, and stories from recent front pages and TV news programs."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

This study was conducted with the aim of developing the academic work in the Palestinian universities. No one can deny the technological stage that we are witnessing in the present era. Our mission is to use this development to develop the educational process. The Artificial Intelligence of the most important branches of computer science, which is interested in the development of computer software in order to make them simulate intelligent human, recently it emerged promised based on artificial intelligence applications are (...) intelligent tutoring system one of the most prominent of these applications is the most useful in the field of education. Intelligent tutoring system are programs that are helping the student and the teacher in the educational process, so that the student exploits these systems to increase his education and the acquisition of scientific skills, and we are not exaggerating if we say that the future of the development of the educational process is through the development of intelligent private teaching systems because it adapts to me intellectual level of the student as well as easy to use and available 24 hours every day. In this study, a smart tutor was designed using the ITSB tool developed by Prof. Sami Abu Nasser to develop the process of teaching the computer skills course. This course is a university course that teaches students of Israa University on different samples of students. After completion of the course, and evaluate the special lecturers who studied the course and used the system in the process of teaching and arrived at a set of conclusions and recommendations make sure that the use of the tutor Smart smartphone is important in the development of laboratory teaching has positive results in improving the level of scientific student . (shrink)

Ambiguity affects decisions of people who exhibit a distaste of and require a premium for dealing with it. Do ambiguity-neutral subjects completely disregard ambiguity and react to any vague news? Online vending platforms often attempt to affect buyer’s decisions by messages like “20 people are looking at this item right now” or “The average score based on 567 reviews is 7.9/10”. We augment the two-color Ellsberg experiment with similarly worded signals about the unknown probability of success. All decision-makers, including ambiguity-neutral, (...) recognize and account for ambiguity; ambiguity-neutral subjects are less likely to respond to vague signals. The difference between decisions of ambiguity-neutral and non-neutral subjects vanishes for high precision signals; still less than 60% subjects choose the ambiguous urn, even for high communicated probabilities of success. We conjecture participants may discard information, if they see no contradiction between it and their prior beliefs, hence the latter are not updated. Higher confidence makes subjects more likely to discard the news, and empirically ambiguity-neutral subjects appear more confident than those ambiguity-averse. (shrink)

This article aims to read feminist new materialisms (Barad), together with ‘postulated’ linguistic or cultural primacy of Queer Theory (Butler), to show how both are engaged in similar critical-ethical endeavours. The central argument is that the criticism of Barad and new materialisms misses Butler’s materialistic insights due to a narrow interpretation of Butler's alleged social-constructivist position. There is, therefore, a specific focus on where they both make similar ethical appeals. Moreover, the article relies on Adorno's negative dialectic to highlight an (...) interpretation of Barad and Butler as being part of the same dialectical movement, in which materialism and idealism fluctuate in their mutual criticisms, thus continuing the procession towards 'new knowledge' and emancipation, or freedom, through their motions back and forth. (shrink)

While individuals presented in central texts of the period are indeed often alone or separated from others, Yousef regards this isolation as a problem the texts attempt to illuminate, rather than a condition they construct as normative or ...

The book challenges the values of much of contemporary bioethics and health care policy by confronting their failure to secure the moral norms they seek to apply.

All geopolitical change represents the creation of a new order and this entails the alteration of the spatial conditions and, therefore, the modification of the way of understanding borders. Carl Schmitt, especially in his last stage, aimed at delineating a new international configuration made up of large spaces (Grossräume), once the time of sovereignties typical of the Ius publicum europaeum was over. The goal of this study is to analizy to which extent and how Schmitt 's analytical tools around borders (...) can be useful to understand the current state of globalization. Todo cambio geopolítico representa la creación de un nuevo orden y ello conlleva la alteración de las condiciones espaciales y, por tanto, la modificación de la manera de entender las fronteras. Carl Schmitt, especialmente en su última etapa, apuntó al delineamiento de una nueva configuración internacional conformada por grandes espacios (Grossräume), una vez que el tiempo de las soberanías propias del Ius publicum europaeum había terminado. El objetivo de este estudio es analizar hasta qué punto y de qué manera las herramientas analíticas de Schmitt en torno a las fronteras pueden ser útiles para comprender el estado actual de la globalización. (shrink)